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Arbutus Biopharma

Scientist, DMPK

DMPK – Warminster, Pennsylvania
Department DMPK
Employment Type Regular Full-Time
Minimum Experience Mid-level

Role Summary

Arbutus Biopharma is seeking an enthusiastic, creative, and highly motivated Bioanalytical Scientist to join the DMPK team at our US headquarters in Warminster, PA. The Scientist provides expertise in the preclinical evaluation and identification of novel compounds for the treatment of HBV. The successful candidate must have strong scientific knowledge of Drug Discovery, DMPK/ADME, and biotransformation. The Scientist will work in close collaboration with the DMPK and Chemistry teams and contract research organizations that are also supporting DMPK functions. The Scientist reports to the Sr. Director, DMPK.

Responsibilities:

Ability to manage deadlines and prioritize effectively, while being able to balance flexibility to achieve established goals.

Intellectually contributes guidance and recommendations in a matrixed team environment that supports the preclinical drug discovery strategy.

Understands and keeps abreast of current FDA guidelines as they pertain to DMPK.

Contributes to expanding and maintaining the teams ADME capabilities, implements new assays.

Effectively troubleshoot assays and LC-MS/MS instruments.

With minimum supervision, routinely develops LC-MS/MS analytical methods, designs and executes non-GLP DMPK experiments, and sample analysis from various ADME assays.

Assesses in vitro and in vivo drug biotransformation and identification of metabolites.

Effectively analyzes and interprets experimental findings, communicates regularly with scientific staff, and presents results at team meetings.

Summarizes results as written reports or in documents to support regulatory filings.

Fosters a spirit of cooperation and teamwork within the laboratory, efficiently coordinates resources within the research team(s) or external organizations.

Other duties as assigned.

Qualifications:

Ph.D. required in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology, Chemistry, Biochemistry, or a related discipline, position requires extensive LC-MS/MS expertise.

A minimum of 3+ years’ experience in the Pharmaceutical or Biotechnology Industry conducting ADME and PK studies focused on small molecule drug discovery.

Proficient knowledge and hands-on experience with DMPK assays that are routinely applied in drug discovery and drug development (i.e., preclinical pharmacokinetics, PK/PD relationships, metabolism, bioanalysis, and in vitro and in vivo techniques applying these concepts)

Ability to manage deadlines and prioritize effectively, while being able to balance some flexibility towards achieving the established goals

Ability to work independently

Solid knowledge in developing and troubleshooting assay methods and instrumentation

Excellent verbal presentation and communication skills required

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  • Location
    Warminster, Pennsylvania
  • Department
    DMPK
  • Employment Type
    Regular Full-Time
  • Minimum Experience
    Mid-level
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