At Arbutus, we have a vision: to cure chronic Hepatitis B virus (HBV). We have a dedicated and innovative team and we are uniquely positioned to transform the HBV treatment landscape. We are developing a portfolio of drug candidates with multiple mechanisms of action that we believe will result in a combination therapy to cure HBV.
If you are looking to join a team with a proven track record in drug discovery and development, and are as passionate as we are, we want to hear from you.
Reporting to the Director of Immunology, the Scientist, Biology will work in close collaboration with senior research staff and peers, in the scientific advancement of both antiviral drug development and immunotherapy programs. In this laboratory based position, the Scientist, Biology will primarily run immunological assays designed to elucidate complex mechanisms of action.
Responsibilities will include:
• Successfully deliver on research goals and objectives
• Design, execution and performance of laboratory experiments including procurement and preparation of materials, in support of primary compound screening, lead optimization programs, mechanism of action studies, and drug combination studies.
• Development and recording of Standard Operating Procedures (SOPs).
• Documenting procedures and results in laboratory notebooks and digital lab management systems, in accordance with appropriate SOPs.
• Working largely independently but under the direction of senior research staff, provide input for improvement and optimization of experimental protocols and interpretation of results.
• Training and mentoring of new staff and interns.
• Other responsibilities as assigned.
• PhD in Immunology or other relevant laboratory-based life science, and 2 years in hands-on biological laboratory research positions; MS degree with minimum 5 years’ experience; or equivalent combination of education and experience.
• Ability to independently execute immunology experiments including isolation of immune cells, T cell proliferation assays, stimulation assays, multi-color flow cytometry, cytokine profiling, luciferase, luminex and ELISAs.
• Expert knowledge of multi-color flow cytometry is required.
• Working knowledge of virus\host interactions including innate and adaptive immune signaling highly preferred.
• Learns quickly and is able to understand and implement new methods.
• Strong organizational and record keeping skills.
• Strong understanding of scientific theory behind research projects.
• Strong command of the literature.
• Strong written and oral communication skills.