Arbutus Biopharma logo

Arbutus Biopharma

Scientist or Research Associate, DMPK

DMPK – Warminster, Pennsylvania
Department DMPK
Employment Type Regular Full-Time
Minimum Experience Experienced

Scientist or Research Associate, DMPK

 Role Summary

 Arbutus Biopharma is searching for an enthusiastic, creative, and highly motivated addition to our Drug Metabolism & Pharmacokinetic (DMPK) team. The employee will actively contribute to the effective application and integration of ADME (adsorption distribution metabolism & elimination) and pharmacokinetic studies that support our discovery efforts to cure HBV.

 Responsibilities will include:

·        Intellectually contributing to the preclinical drug discovery strategy and provides feedback and recommendations.

·         Designing and performing DMPK studies including in vitro metabolic stability, P450 inhibition and induction, in vivo pharmacokinetics / ADME, and drug interaction studies.

·         Reviewing and summarizing results, integrating ADME, PK, and PK/PD information that guide multi-disciplinary team efforts in lead optimization and to facilitate selection of development candidates.

·         Delivering on established DMPK research goals and objectives.

·         Effectively presenting results at project team meetings.

·         Working with CROs to meet project needs

·         Working in a matrixed team environment and fosters a spirit of cooperation and teamwork

Qualifications:

·     Ph.D. with a minimum of two (2) years at the Scientist level or a BSc with four-plus (4+) years of experience in a pharmaceutical or biotechnology company for the Associate level is required

·        Graduate or undergraduate degree is from an accredited institution in biology, biochemistry, pharmaceutical sciences, or related scientific discipline

·         Proficient knowledge and hands-on experience with DMPK assays that are routinely applied in drug discovery and drug development (i.e., preclinical pharmacokinetics, PK/PD relationships, metabolism, bioanalysis, and in vitro and in vivo techniques applying these concepts)

·         Quantitative and qualitative experience with LC-MS/MS, in vitro and in vivo biotransformation, and human PK and drug interaction predictions is desirable

·         Proven problem-solving ability

·         Ability to manage deadlines and prioritize effectively

·         Solid knowledge in developing and troubleshooting assay methods

·         Excellent verbal presentation and communication skills

·         Mature and proven ability to work independently or collaboratively as required

Thank You
Your application was submitted successfully.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Apply for this Job
  • Location
    Warminster, Pennsylvania
  • Department
    DMPK
  • Employment Type
    Regular Full-Time
  • Minimum Experience
    Experienced
  • Powered by