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Arbutus Biopharma

Scientist or Research Associate, DMPK

DMPK – Warminster, Pennsylvania
Department DMPK
Employment Type Regular Full-Time
Minimum Experience Experienced

Scientist or Research Associate, DMPK

 Role Summary

 Arbutus Biopharma is searching for an enthusiastic, creative, and highly motivated addition to our Drug Metabolism & Pharmacokinetic (DMPK) team. The employee will actively contribute to the effective application and integration of ADME (adsorption distribution metabolism & elimination) and pharmacokinetic studies that support our discovery efforts to cure HBV.

 Responsibilities will include:

·        Intellectually contributing to the preclinical drug discovery strategy and provides feedback and recommendations.

·         Designing and performing DMPK studies including in vitro metabolic stability, P450 inhibition and induction, in vivo pharmacokinetics / ADME, and drug interaction studies.

·         Reviewing and summarizing results, integrating ADME, PK, and PK/PD information that guide multi-disciplinary team efforts in lead optimization and to facilitate selection of development candidates.

·         Delivering on established DMPK research goals and objectives.

·         Effectively presenting results at project team meetings.

·         Working with CROs to meet project needs

·         Working in a matrixed team environment and fosters a spirit of cooperation and teamwork

Qualifications:

·     Ph.D. with a minimum of two (2) years at the Scientist level or a BSc with four-plus (4+) years of experience in a pharmaceutical or biotechnology company for the Associate level is required

·        Graduate or undergraduate degree is from an accredited institution in biology, biochemistry, pharmaceutical sciences, or related scientific discipline

·         Proficient knowledge and hands-on experience with DMPK assays that are routinely applied in drug discovery and drug development (i.e., preclinical pharmacokinetics, PK/PD relationships, metabolism, bioanalysis, and in vitro and in vivo techniques applying these concepts)

·         Quantitative and qualitative experience with LC-MS/MS, in vitro and in vivo biotransformation, and human PK and drug interaction predictions is desirable

·         Proven problem-solving ability

·         Ability to manage deadlines and prioritize effectively

·         Solid knowledge in developing and troubleshooting assay methods

·         Excellent verbal presentation and communication skills

·         Mature and proven ability to work independently or collaboratively as required

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  • Location
    Warminster, Pennsylvania
  • Department
    DMPK
  • Employment Type
    Regular Full-Time
  • Minimum Experience
    Experienced
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